Which of the following is a side effect associated with Tricyclic Antidepressants (TCA)?

• A. Thrombocytopenia
• B. Hypertension
• C. Pneumonia
• D. Insomnia

Answer: (A)

The side effect associated with Tricyclic Antidepressants (TCA) that is most commonly recognized is not thrombocytopenia, but rather effects related to their anticholinergic properties which can include sedation. Tricyclic antidepressants can cause various side effects based on their pharmacological profile.

Among the options provided, hypertension can occur with some TCAs due to their impact on norepinephrine reuptake but is not the most typical side effect. Pneumonia is not a direct side effect of TCAs, and while insomnia can occur as a secondary effect of certain medications, it is not a typical side effect of TCAs which often induce sedation.

In summary, the side effects of TCAs are more closely aligned with sedation, anticholinergic effects (like dry mouth, blurred vision, constipation), and cardiac issues (arrhythmias) rather than thrombocytopenia. Understanding TCA side effects helps in monitoring and managing patients effectively during treatment.